Biotransformation Is Carried Out by the Following Organ: _____

Biotransformation is carried out by the following organ: _____.It usually involves making a drug _____ water soluble.The increased ability of this organ to carry out biotransformation after repeated exposure to a drug is termed _____ tolerance.The increased ability of this organ to biotransform drugs other than the one administered previously is termed _____.

A) small intestine; more; metabolic; cross-tolerance
B) kidneys; less; metabolic; cellular-adaptive
C) liver; less; pharmacodynamic; cross-tolerance
D) liver; more; metabolic; cross-tolerance