The time to reach steady-state concentrations of a drug,that is,the level of drug achieved in the blood with repeated,regular-interval dosing,is:

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The time to reach steady-state concentrations of a drug is achieved when the amount of drug administered per unit time equals the amount eliminated per unit time. This is independent of the actual dosage of the drug, as long as the dosing interval remains constant. The time to reach steady-state concentration is also dependent on the drug's half-life, which determines the rate of elimination. Generally, it takes about four to five half-lives to reach steady-state concentrations. Therefore, the time to reach steady-state concentrations is not reached after only one elimination half-life.

The Time to Reach Steady-State Concentrations of a Drug,that Is,the