The reduction in the number or sensitivity of receptors in response to prolonged activation by a drug is known as:

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Down regulation refers to the process by which the body decreases the number or sensitivity of receptors in response to prolonged activation by a drug. This results in decreased drug effectiveness and increased tolerance. Metabolic tolerance refers to the body's ability to break down and eliminate drugs more efficiently over time. Homeostasis refers to the body's ability to maintain a stable internal environment despite external changes. Physical dependence refers to the body's reliance on a drug to function normally, which can result in withdrawal symptoms when the drug is discontinued.

The Reduction in the Number or Sensitivity of Receptors in Response