The landmark significance of the Protestant Reformation was the fact that it

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The Protestant Reformation led to a significant break in the religious unity of Western Christendom as new Protestant denominations, like Lutheranism and Calvinism, appeared and challenged the authority of the Catholic Church. This led to conflicts like the Thirty Years War and changes in European society that shaped the modern world. The Reformation did not lead to the Italian Renaissance nor did it enhance the Catholic Church's influence in Northern Europe. Therefore, choices A, B, and D are incorrect.

The Landmark Significance of the Protestant Reformation Was the Fact