The Concept of "Induced Fit" Refers to the Fact That

The concept of "induced fit" refers to the fact that:

A) enzyme specificity is induced by enzyme-substrate binding.
B) enzyme-substrate binding induces an increase in the reaction entropy, thereby catalyzing the reaction.
C) enzyme-substrate binding induces movement along the reaction coordinate to the transition state.
D) substrate binding may induce a conformational change in the enzyme, which then brings catalytic groups into proper orientation.
E) when a substrate binds to an enzyme, the enzyme induces a loss of water (desolvation) from the substrate.