The combination of amoxicillin and clavulanic acid into the drug known as Augmentin is widely used as an antibacterial agent. The purpose of amoxicillin in this drug is to target _____, which catalyzes crosslinking of peptidoglycan, and the purpose of clavulanic acid in this drug is to target _____, which normally would inactivate the amoxicillin. Both of these compounds act as _____ inhibitors of enzyme function.
A) transpeptidase; hexokinase; competitive
B) peptidoglycanase; $\beta$ lactamase; uncompetitive
C) transpeptidase; $\beta$ lactamase; suicide
D) glycanprotease; penicillinase; competitive
E) $\beta$ lactamase; lysozyme; suicide

Question

Quizplus · Accepted Answer

Amoxicillin targets transpeptidase, which catalyzes crosslinking of peptidoglycan, while clavulanic acid targets F1F1F1S1F1F1F10 lactamase, which normally would inactivate the amoxicillin. Both compounds act as suicide inhibitors of enzyme function, meaning that they irreversibly bind to and permanently disable the enzymes.

The Combination of Amoxicillin and Clavulanic Acid into the Drug β\betaβ

The Combination of Amoxicillin and Clavulanic Acid into the Drug $\beta$