The amino acid substitution of Val for Glu in Hemoglobin S results in aggregation of the protein because of _____ interactions between molecules.

Question

Quizplus · Accepted Answer

The substitution of Val for Glu in Hemoglobin S leads to the formation of a hydrophobic patch on the surface of the molecule. This patch promotes the aggregation of Hemoglobin S molecules, leading to the characteristic sickling behavior of red blood cells in individuals with sickle cell anemia.

The Amino Acid Substitution of Val for Glu in Hemoglobin