Which mutation would be MOST likely to result in amyloid formation?
A) Lys $\rightarrow$ Arg
B) Gln $\rightarrow$ Glu
C) Lys $\rightarrow$ Phe
D) Tyr $\rightarrow$ His
E) Trp $\rightarrow$ Ile

Question

Quizplus · Accepted Answer

The mutation from Lys to Phe (C) introduces a hydrophobic residue (phenylalanine) in place of a hydrophilic one (lysine), which increases the propensity for the protein to misfold and form amyloid fibrils due to enhanced hydrophobic interactions.

Which Mutation Would Be MOST Likely to Result in Amyloid →\rightarrow→

Which Mutation Would Be MOST Likely to Result in Amyloid $\rightarrow$