Briefly describe the biochemical role of the following enzymes in DNA replication in E. coli:
(a) DNA helicase; (b) primase; (c) the 3' 5' exonuclease activity of DNA polymerase; (d) DNA 1igase; (e) topoisomerases; (f) the 5' 3' exonuclease activity of DNA polymerase I.
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