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Phenformin Is a Biguanide Similar to Metformin

Question 98

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Phenformin is a biguanide similar to metformin. It was used in the treatment of type 2 diabetes but was pulled from clinical use because it was associated with the potentially fatal side-effect of lactic acidosis. Provide a rational for this. (Hint: Biguanides enhance anaerobic metabolism.)

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Phenformin, like metformin, is a biguani...

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