When Water Is Found in a Crystal Structure of a Biomolecule

When water is found in a crystal structure of a biomolecule, which statement is NOT true?

A) The properties of the bound water molecules are different from those of the "bulk" water of the solvent.
B) The bound water molecules may provide a path for "proton hopping."
C) The bound water molecules can form an essential part of the protein's ligand binding site.
D) The orientation of bound water molecules is precise.
E) All of the statements are true.