Which Statement Is FALSE Regarding Regulation of the Pyruvate Dehydrogenase

Which statement is FALSE regarding regulation of the pyruvate dehydrogenase complex?

A) In E. coli, a high ratio of [NAD⁺]/[NADH] activates the complex.
B) In E. coli, high levels of ATP enhance the activity of pyruvate dehydrogenase kinase.
C) In plants, NH₄⁺ inhibits the complex by enhancing the activity of pyruvate dehydrogenase kinase.
D) In mammals, both fatty acids and acetyl-CoA inhibit the complex.
E) In skeletal muscle, both NAD⁺ and Ca₂⁺ activate the complex.