Which statement is TRUE for the reciprocal regulation of phosphofructokinase-1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1)?
A) Fructose 2,6-bisphosphate inhibits FBPase-1 and activates PFK-1.
B) Fructose 2,6-bisphosphate inhibits PFK-1 and activates FBPase-1.
C) Fructose 1,6-bisphosphate inhibits FBPase-1 and activates PFK-1.
D) Fructose 1,6-bisphosphate inhibits PFK-1 and activates FBPase-1.

Question

Quizplus · Accepted Answer

Fructose 2,6-bisphosphate is a potent regulator of glycolysis and gluconeogenesis, where it activates phosphofructokinase-1 (PFK-1) to promote glycolysis and inhibits fructose 1,6-bisphosphatase (FBPase-1) to suppress gluconeogenesis, thus facilitating the reciprocal regulation of these pathways.

Which Statement Is TRUE for the Reciprocal Regulation of Phosphofructokinase-1