Which factor does NOT contribute to the large, negative, free-energy change upon hydrolysis of "high-energy" compounds?
A) electrostatic repulsion in the reactant
B) low activation energy of forward reaction
C) stabilization of products by extra resonance forms
D) stabilization of products by ionization
E) stabilization of products by solvation

Question

Quizplus · Accepted Answer

A low activation energy would actually contribute to a large, negative, free-energy change upon hydrolysis of "high-energy" compounds, as it allows the reaction to proceed more readily. The other choices (A, C, D, and E) all contribute to the stabilization of the products, which lowers their free energy and leads to a larger, negative delta G.

Which Factor Does NOT Contribute to the Large, Negative, Free-Energy