Which statement is NOT true for G protein-coupled receptors (GPCRs)?
A) Agonists mimic the effect of the natural ligand.
B) Antagonists block the normal effect of the natural ligand.
C) GPCRs interact with heterodimeric G proteins.
D) GPCRs are have seven transmembrane helices.
E) There exist 100 orphan GPCRs in the human genome with no known ligand.

Question

Which statement is NOT true for G protein-coupled receptors (GPCRs)?
A) Agonists mimic the effect of the natural ligand.
B) Antagonists block the normal effect of the natural ligand.
C) GPCRs interact with heterodimeric G proteins.
D) GPCRs are have seven transmembrane helices.
E) There exist >100 orphan GPCRs in the human genome with no known ligand.

Quizplus · Accepted Answer

GPCRs interact with heterotrimeric G proteins, not heterodimeric.

Which Statement Is NOT True for G Protein-Coupled Receptors (GPCRs)