In the insulin-receptor-dependent activation of the protein ERK (extracellular regulated kinase), what protein is responsible for phosphorylating ERK?

Question

Quizplus · Accepted Answer

MEK is responsible for phosphorylating ERK in the insulin-receptor-dependent activation pathway. INSR and IRS-1 are involved in activating signaling cascades, but they do not directly phosphorylate ERK. Raf-1 kinase and Ras are upstream of MEK in the pathway and are involved in activating MEK.

In the Insulin-Receptor-Dependent Activation of the Protein ERK (Extracellular Regulated