Direct thrombin inhibitors include lepirudin and argatroban; they:

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Direct thrombin inhibitors, such as lepirudin and argatroban, are often used when a patient develops heparin-induced thrombocytopenia (HIT). They do not require binding to antithrombin to provide their anticoagulant effect and they do not bind all serine proteases. They are not usually monitored using the PT (prothrombin time), but rather the aPTT (activated partial thromboplastin time).

Direct Thrombin Inhibitors Include Lepirudin and Argatroban; They