A patient sample has normal platelet aggregation patterns for all agonists except that no reaction occurs with ristocetin. Ristocetin agglutination is not corrected with exogenous VWF. What condition is most likely?

Question

Quizplus · Accepted Answer

The lack of platelet aggregation with ristocetin and the fact that exogenous VWF does not correct the agglutination suggests a deficiency or dysfunction of the platelet GPIb-V-IX receptor, which is a characteristic of Bernard-Soulier syndrome. VWD, storage pool disorders, and aspirin use would not specifically affect the platelet response to ristocetin.

A Patient Sample Has Normal Platelet Aggregation Patterns for All