A 27-year-old woman arrives at the emergency department with acute bleeding and is found to have a white count of 25.7 *10⁹L with pancytopenia: hematocrit 27%, platelet count 35*10⁹/L, and absolute neutrophil count 0.8 * 10⁹/L. She has a combination of 97% blasts and abnormal promyelocytes in her peripheral blood; some of these cells contain stacked Auer rods. What form of leukemia does she most likely have?

Question

Quizplus · Accepted Answer

The combination of acute bleeding, pancytopenia, and high percentage of blasts (97%) with abnormal promyelocytes containing stacked Auer rods is classic for acute promyelocytic leukemia (APL), which is a subtype of acute myeloid leukemia (AML) with t(15;17)(q22:q12). The other answer choices are unlikely as they do not fit the described clinical picture.

A 27-Year-Old Woman Arrives at the Emergency Department with Acute