Which of the following conditions is associated with a deficiency of von Willebrand factor (VWF)-cleaving protease?

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Thrombotic thrombocytopenic purpura (TTP) is associated with a deficiency of Von Willebrand factor (VWF)-cleaving protease, also known as ADAMTS13. Deficiency of this enzyme leads to the accumulation of ultra-large VWF multimers, causing microthrombi formation in small vessels and platelet consumption, resulting in thrombocytopenia and microangiopathic hemolytic anemia. Hemolytic uremic syndrome is also associated with microangiopathic hemolytic anemia and thrombocytopenia but is caused by different mechanisms. March hemoglobinuria is a condition associated with the destruction of red blood cells during marching, and DIC is a condition associated with increased clotting and bleeding tendencies.

Which of the Following Conditions Is Associated with a Deficiency