What causes the destruction of red cells in hereditary spherocytosis?

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Quizplus · Accepted Answer

In hereditary spherocytosis, red cells have a spherical shape due to a defective cytoskeletal protein that results in decreased deformability. As a result, these cells become trapped and damaged in the splenic sinusoids, where they are targeted and phagocytosed by splenic macrophages. This results in hemolysis and anemia. Complement activation and autoantibodies are not typically involved in the destruction of red cells in hereditary spherocytosis.

What Causes the Destruction of Red Cells in Hereditary Spherocytosis