What make RBCs settle faster through the plasma when inflammation or infection exist?

Question

Quizplus · Accepted Answer

Acute phase reactant proteins, such as fibrinogen and C-reactive protein, can disrupt the electrical charge that normally separates red blood cells, causing them to clump together and settle faster through the plasma. This is known as the erythrocyte sedimentation rate (ESR), which is a common marker for inflammation and infection. Bacteria do not directly cause red cells to agglutinate, and the increased number of neutrophils may contribute to the formation of rouleaux, but this is not the primary reason for faster settling. Inflammation may actually increase plasma viscosity due to increased levels of fibrinogen and other proteins, which would slow down erythrocyte sedimentation.

What Make RBCs Settle Faster Through the Plasma When Inflammation