What directs the mitosis and maturation action of progenitor neutrophil cells in the bone marrow?

Question

Quizplus · Accepted Answer

Colony-stimulating cytokines, such as granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF), play a pivotal role in directing the mitosis and maturation of progenitor neutrophil cells in the bone marrow. These cytokines activate specific receptors on progenitor cells, leading to cell division, differentiation, and maturation into mature neutrophils. Erythropoietin primarily stimulates the production of red blood cells, and the number of stem cells and mature cells in the peripheral circulation do not directly regulate neutrophil maturation in the bone marrow.

What Directs the Mitosis and Maturation Action of Progenitor Neutrophil