Why is heme located inside a globin chain pocket surrounded by hydrophobic amino acids?

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Quizplus · Accepted Answer

Heme is located inside a globin chain pocket surrounded by hydrophobic amino acids to protect the iron from being oxidized to its ferric form. This is crucial because the iron in its ferrous state (Fe2+) is necessary for oxygen binding and transport. Oxidation to the ferric state (Fe3+) would impair hemoglobin's ability to carry oxygen.

Why Is Heme Located Inside a Globin Chain Pocket Surrounded