What mechanism is responsible for the destruction of the majority of normal senescent erythrocytes?

Question

Quizplus · Accepted Answer

Phagocytosis by splenic macrophages is the mechanism responsible for the destruction of the majority of normal senescent erythrocytes. The spleen removes old or abnormal red blood cells (RBCs) by trapping them in narrow capillaries and destroying them through phagocytosis by splenic macrophages. This process of removing senescent RBCs is known as extravascular hemolysis. Intravascular hemolysis refers to the processes that destroy red blood cells within blood vessels, but this is not the primary mechanism for the destruction of normal senescent erythrocytes. Rupture by complement and phagocytosis by peripheral neutrophils are not major mechanisms responsible for the destruction of normal senescent erythrocytes.

What Mechanism Is Responsible for the Destruction of the Majority