The brain is the ultimate source of our pleasures and joys as well as our sorrows and pains. According to the text,this knowledge was evident as early as

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The text does not mention A.D. or B.C. dates, but it does reference the philosopher Aristotle who lived from 384-322 B.C. and wrote about the relationship between the brain and pleasure/pain in his book "The Nicomachean Ethics". Therefore, the knowledge that the brain is the source of pleasure and pain was evident as early as 377 B.C.

The Brain Is the Ultimate Source of Our Pleasures and Joys