The conversion of isocitrate to α-ketoglutarate in step 3 of the citric acid cycle involves which of the following sequences of reactions?

Question

Quizplus · Accepted Answer

The conversion of isocitrate to α-ketoglutarate involves first oxidizing the secondary alcohol at C-2 to a ketone, followed by decarboxylation to remove a CO2 group, resulting in the formation of α-ketoglutarate. Therefore, the correct sequence of reactions is oxidation followed by decarboxylation, which is represented by option C.

The Conversion of Isocitrate to α-Ketoglutarate in Step 3 of the Citric