How do compounds such as 2,4-dinitrophenol, DNP, work as weight reducing drugs?

Question

Quizplus · Accepted Answer

DNP is a protonophore, meaning it disrupts the chemiosmotic pump (also known as the electron transport chain) in mitochondria by transporting protons directly through the lipid bilayer instead of through the normal proton channels. This uncouples oxidative phosphorylation, which normally synthesizes ATP from the proton gradient generated by the electron transport chain. Instead, the energy generated by electron transport is released as heat, which can increase the body's metabolic rate and cause weight loss. However, DNP is highly toxic and can lead to many serious side effects, including death.

How Do Compounds Such as 2,4-Dinitrophenol, DNP, Work as Weight