Which of the following represents the overall transformation when a carboxylic acid is converted to an amide?

Question

Quizplus · Accepted Answer

The transformation from a carboxylic acid to an amide involves the combining of the fragments which remain after the loss of −OH from the carboxylic acid and −H from ammonia or an amine. This results in the formation of a carbonyl group, which is shared by both the carboxylic acid and the amine, and which forms the peptide bond in proteins. Option B involves the loss of −OH from the carboxylic acid and −H from an alcohol, which would result in the formation of an ester. Option C involves the loss of an oxygen atom from the carboxylic acid, which would result in the formation of an aldehyde or a ketone, and is not relevant to the transformation to an amide.

Which of the Following Represents the Overall Transformation When a Carboxylic