The citric acid cycle begins when acetyl-CoA combines with _____ to form _____.

Question

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The citric acid cycle begins when acetyl-CoA combines with oxaloacetate to form citrate. This is the first step of the cycle and is catalyzed by the enzyme citrate synthase. Choice A is incorrect because pyruvate is not a part of the citric acid cycle. Choice B is incorrect because malate is not involved in the initial step of the cycle. Choice C is incorrect because it describes a step that occurs later in the cycle. Choice E is incorrect because cis-aconitate is an intermediate, not a starting compound.

The Citric Acid Cycle Begins When Acetyl-CoA Combines with _____