Oligomycin is an antibiotic that binds ATP synthase, blocking the flow of protons through the enzyme's proton channel. In addition to preventing synthesis of ATP, what additional effect might you expect in response to the presence of oligomycin?

Question

Quizplus · Accepted Answer

Oligomycin blocks the flow of protons through the proton channel of ATP synthase, which increases the proton gradient across the inner mitochondrial membrane. This leads to a decrease in pH in the intermembrane space, as protons accumulate there due to the inability to flow through ATP synthase.

Oligomycin Is an Antibiotic That Binds ATP Synthase, Blocking the Flow