Suppose that three critical amino acids in the active site of a specific enzyme are arginine, lysine, and histidine. Which of the following characteristics would you predict the substrate to possess in order to bind the active site of this enzyme?
A)relatively hydrophobic
B)hydrophilic, with a negative charge
C)hydrophilic, with a positive charge
D)hydrophilic, but without a charge

Question

Quizplus · Accepted Answer

The substrate would likely be hydrophilic with a negative charge because arginine, lysine, and histidine are all positively charged at physiological pH, suggesting that they would interact favorably with negatively charged substrates.

Suppose That Three Critical Amino Acids in the Active Site