Suppose that three critical amino acids in the active site of a specific enzyme are threonine, serine, and glutamic acid. Which of the following characteristics would you predict the substrate to possess in order to bind the active site of this enzyme?
A)relatively hydrophobic
B)hydrophilic, with a negative charge
C)hydrophilic, with a positive charge
D)hydrophilic, but without a charge

Question

Quizplus · Accepted Answer

Given the amino acids threonine, serine, and glutamic acid in the active site, the substrate likely needs to be hydrophilic due to the polar nature of threonine and serine. Glutamic acid, being negatively charged, suggests the substrate should have a positive charge to facilitate binding through electrostatic interactions.

Suppose That Three Critical Amino Acids in the Active Site