If a mutation rendered the signal recognition particle receptor nonfunctional such that it is no longer able to dissociate from the SRP, what would be the most obvious effect on the cell?
A)Translation of most proteins would be incomplete.
B)All proteins normally secreted by the cell would remain partially formed and attached to the endoplasmic reticulum.
C)Proteins destined for the nucleus would remain in the cytosol.
D)No proteins would arrive at their proper destinations within the cell.
E)All proteins normally secreted by the cell would remain in the cytosol.

Question

Quizplus · Accepted Answer

The signal recognition particle receptor is responsible for recognizing the signal peptide on nascent polypeptides and directing them to the endoplasmic reticulum for secretion or membrane insertion. If the receptor is nonfunctional and unable to dissociate from the signal recognition particle, the protein would not be properly targeted to the endoplasmic reticulum and would remain partially formed and attached to the membrane, leading to the accumulation of misfolded proteins and potential cellular dysfunction. This would primarily affect proteins intended for secretion, hence option B is the correct answer.

If a Mutation Rendered the Signal Recognition Particle Receptor Nonfunctional