A Mutation Is Found That Prevents Transcription of the HOX3A

A mutation is found that prevents transcription of the HOX3A gene, which is known to be in chromosome 12. Genetic mapping of the mutation suggests that it is located in chromosome 11. Which of the following could make these two observations possible?

A) The mutation affects a transcription factor that binds to HOX3A gene sequences.
B) The mutation changes the DNA sequence of an enhancer of the HOX3A gene.
C) The mutation prevents ribosome binding by altering sequences of the HOX3A mRNA.
D) The mutation increases transcription of an miRNA that has sequence homology to the HOX3A gene.