Transcriptional regulation of lac operon by repressor protein and cAMP-receptor protein (CRP) is an example of:

Question

Quizplus · Accepted Answer

Combinatorial control refers to the regulation of gene expression by multiple transcription factors or regulatory proteins working together to regulate a gene or set of genes. In the case of the lac operon, both the repressor protein and the cAMP-CRP complex are required for optimal regulation of the operon. The repressor protein binds to the operator site and prevents RNA polymerase from transcribing the genes in the lac operon, while the cAMP-CRP complex binds to a DNA site upstream of the promoter and activates transcription by promoting RNA polymerase binding. Together, these two regulatory proteins work in a combinatorial manner to regulate the expression of the lac operon.

Transcriptional Regulation of Lac Operon by Repressor Protein and CAMP-Receptor