Inheritance due to a rare X-linked dominant mutation can be distinguished from inheritance due to a rare autosomal dominant mutation because, in the X-linked case:

Question

Quizplus · Accepted Answer

Affected fathers do not have affected sons in the case of X-linked dominant inheritance because fathers pass their Y chromosome to their sons, not their X chromosome. In contrast, affected fathers can pass an autosomal dominant mutation to any child regardless of gender.

Inheritance Due to a Rare X-Linked Dominant Mutation Can Be