The diagrams below depict the relative proportions of individuals affected with a certain condition (shaded bar) and individuals not affected (open bar), in individuals carrying either the A-T or the G-C allele of an SNP polymorphism. (Heterozygous genotypes carry both alleles and are included in both categories.) Which graph shows a pattern that suggests that the G-C allele is a risk factor for the disease?

Question

The diagrams below depict the relative proportions of individuals affected with a certain condition (shaded bar) and individuals not affected (open bar), in individuals carrying either the A-T or the G-C allele of an SNP polymorphism. (Heterozygous genotypes carry both alleles and are included in both categories.)  Which graph shows a pattern that suggests that the G-C allele is a risk factor for the disease?

Quizplus · Accepted Answer

Graph D shows a significantly higher proportion of affected individuals among those carrying the G-C allele compared to those carrying the A-T allele. This suggests that the G-C allele may be a risk factor for the disease. The other graphs do not show a clear pattern suggesting a risk factor allele.

The Diagrams Below Depict the Relative Proportions of Individuals Affected