The diagrams below depict the relative proportions of individuals affected with a certain condition (shaded bar) and individuals not affected (open bar), in individuals carrying either the A-T or the G-C allele of an SNP polymorphism. (Heterozygous genotypes carry both alleles and are included in both categories.) Which panel shows a pattern that suggests that the A-T allele is a factor that protects against the disease?

Question

The diagrams below depict the relative proportions of individuals affected with a certain condition (shaded bar) and individuals not affected (open bar), in individuals carrying either the A-T or the G-C allele of an SNP polymorphism. (Heterozygous genotypes carry both alleles and are included in both categories.)  Which panel shows a pattern that suggests that the A-T allele is a factor that protects against the disease?

Quizplus · Accepted Answer

In graph C, the proportion of individuals affected with the condition is significantly lower in individuals carrying the A-T allele compared to those carrying the G-C allele. This suggests that the A-T allele may be protective against the disease. In contrast, the other graphs do not show a clear pattern that suggests a protective effect of the A-T allele.

The Diagrams Below Depict the Relative Proportions of Individuals Affected