The most common form of hemophilia is a defect in blood clotting factor VIII, which is caused by a mutant form of a gene in the X chromosome. A girl is born with hemophilia. Both parents have normal phenotypes. Which of the following might explain this girl's hemophilia?
A) A nondisjunction event in sperm production resulted in her receiving X and Y chromosomes from her father, and an X from her mother; she is XXY.
B) Nondisjunction during egg formation resulted in her receiving no X chromosome from her mother, but an X from her father; she is XO.
C) Nondisjunction during sperm formation resulted in her receiving no sex chromosome from her father and an X chromosome from her mother; she is XO.
D) Nondisjunction during egg formation resulted in her receiving two X chromosomes from her mother and an X chromosome from her father; she is XXX.
E) She inherited an X chromosome from her father and the X carrying the defective allele from her mother.
Correct Answer:
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