It has been estimated that the average human gamete contains about 30 new nucleotide-substitution mutations and approximately 3 new small insertions or deletions (indels). Assuming a human genome size of 3 × 10⁹ base pairs, what is the estimated rate of nucleotide-substitution mutations and of indel mutations per nucleotide pair per generation?

Question

Quizplus · Accepted Answer

The rate of nucleotide-substitution mutations is 30 mutations per 3 × 10⁹ base pairs, which is 10^-8. The rate of indel mutations is 3 mutations per 3 × 10⁹ base pairs, which is 10^-9.

It Has Been Estimated That the Average Human Gamete Contains