Which of the Following Statements Applies to Frameshift Mutations

Which of the following statements applies to frameshift mutations?

A) They cause the insertion or deletion of a single amino acid from the polypeptide chain.
B) They create a premature stop codon at the site of mutation.
C) They change the amino acid sequence downstream from the mutant site.
D) They are known risk factors in most forms of cancer, including breast and colon cancer.
E) They are known risk factors in breast cancer, but not colon cancer.