A daughter strand of DNA produced during chromosome replication can be composed of leading and lagging strands from different replication bubbles.

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During chromosome replication, the two strands of DNA separate and each serves as a template for the synthesis of a new complementary strand. Replication bubbles can form at various points along the DNA molecule as the replication machinery moves along. The leading strand is synthesized continuously in the direction of replication fork movement, while the lagging strand is polymerized in the opposite direction in short, discontinuous Okazaki fragments. Since the replication bubbles may merge or separate during the replication process, it is possible for a daughter strand to include leading and lagging strands from different bubbles.

A Daughter Strand of DNA Produced During Chromosome Replication Can