Which one of the following would MOST likely contribute to uncontrolled cell proliferation (i.e., cancer)?

Question

Quizplus · Accepted Answer

A mutant CDK that was active in the absence of its cyclin binding partner would cause uncontrolled cell proliferation, as CDKs are responsible for regulating the cell cycle and a mutation in the CDK could result in a loss of control over cell division. Mutations in cyclins, enzymes involved in microtubule synthesis/polymerization, and kinetochore proteins could also potentially contribute to cancer by disrupting proper cell cycle regulation and chromosome segregation, but a mutant CDK is the most likely to directly cause uncontrolled cell proliferation. Similarly, a mutation in the DNA replication mechanism could lead to chromosomal aberrations that may contribute to cancer, but it is not as direct a cause as a mutation in a cell cycle regulatory protein like CDK.

Which One of the Following Would MOST Likely Contribute to Uncontrolled