How would the loss of p53 activity affect a cell?

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Quizplus · Accepted Answer

Loss of p53 activity would affect all of these aspects in a cell. The p53 protein plays a crucial role in regulating the cell cycle and responding to DNA damage. Without p53 function, the checkpoints that monitor DNA damage and ensure repair before entering mitosis, such as the G₁/S checkpoint, would not be functional. Additionally, p53 plays a role in preventing the replication of cells with damaged DNA, which could lead to the accumulation of DNA damage. Finally, p53 regulates CDK activity, which is necessary for progression through the cell cycle. Without proper regulation of CDK activity, cells could enter mitosis with damaged DNA or in an uncontrolled manner, leading to genomic instability and potentially cancer.

How Would the Loss of P53 Activity Affect a Cell