Malignancies Develop Stepwise Over Time Because

Malignancies develop stepwise over time because:

A) it takes time for a benign tumor to be able to dissolve through its encapsulation before it can invade neighboring tissues.
B) benign tumor cells divide slowly and in a stepwise pattern.
C) it takes multiple mutations of multiple genes to allow cancer cells to develop.
D) cells keep leaving the benign tumor and are destroyed in lymph nodes.
E) All of these choices are correct.