The 1964 Surgeon General's report on the dangers of smoking was one of the studies that led to widespread lifestyle changes and lowering of cardiovascular disease rates. The other influential study was

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The Framingham Heart Study, a long-term research project that began in 1948, tracked the health outcomes of thousands of participants over several decades. It was one of the earliest studies to identify risk factors for cardiovascular disease, including smoking, high blood pressure, and high cholesterol. The findings from this study had a significant impact on public health policies and led to increased awareness and prevention of cardiovascular disease.

The 1964 Surgeon General's Report on the Dangers of Smoking