Select the best reagent to convert 4,5-dimethylhex-2-yne to 4,5-dimethylhex-1-yne.

Question

Quizplus · Accepted Answer

The correct reagent for converting 4,5-dimethylhex-2-yne to 4,5-dimethylhex-1-yne involves moving the triple bond from the 2-position to the 1-position. This can be achieved through anti-Markovnikov addition of hydrogen across the triple bond, which is facilitated by the use of sodium amide (NaNH2) to generate the terminal alkyne, followed by acid workup. Sodium amide is a strong base that can deprotonate the terminal alkyne, and the subsequent acid workup (H3O+) neutralizes the base and helps to stabilize the final product. This process effectively shifts the triple bond from an internal position to a terminal position without adding any additional groups to the molecule.

Select the Best Reagent to Convert 4,5-Dimethylhex-2-Yne to 4,5-Dimethylhex-1-Yne