Inhibition of an enzyme is irreversible when

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Irreversible inhibition occurs when covalent bonds form between the inhibitor and enzyme. This is in contrast to reversible inhibition, which can be overcome by increasing substrate concentration or removing the inhibitor from the system. Competitive and noncompetitive inhibition are both reversible. A change in the shape of the enzyme may also result in inhibition, but this could be reversible or irreversible depending on the cause of the shape change.

Inhibition of an Enzyme Is Irreversible When