Hurler and Sanfilippo syndromes present with mental retardation and an increase in what urinary constituent:

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Hurler and Sanfilippo syndromes are both mucopolysaccharidoses, which are lysosomal storage disorders characterized by an inability to degrade certain glycosaminoglycans (GAGs). As a result, GAGs accumulate in tissues and are excreted in the urine, leading to an increase in urinary mucopolysaccharides (also known as GAGs or dermatan sulfate/heparan sulfate).

Hurler and Sanfilippo Syndromes Present with Mental Retardation and an Increase